2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-145504
    12-Dipalmitoyl-3-Linoelaidoyl-rac-glycerol 344791-14-6 98%
    12-Dipalmitoyl-3-Linoelaidoyl-rac-glycerol is a triacylglycerol containing palmitic acid (HY-N0830) at the sn-1 and sn-2 positions and linoelaidic acid (HY-W071746) at the sn-3 position. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Linolelaidic acid, an omega-6 trans fatty acid, acts as a source of energy. Linolelaidic acid is an essential nutrient, adding in enteral, parenteral, and infant formulas. Linolelaidic acid can be used for heart diseases research.
    12-Dipalmitoyl-3-Linoelaidoyl-rac-glycerol
  • HY-145508
    1,2-Dilauroyl-sn-glycero-3-PG sodium 322647-27-8 98%
    1,2-Dilauroyl-sn-glycero-3-PG (1,2-Didodecanoyl-sn-glycero-3-phospho-(1′racglycerol)) sodium is a phospholipid containing 12:0 fatty acids that exhibits excellent surfactant properties.
    1,2-Dilauroyl-sn-glycero-3-PG sodium
  • HY-145510
    1,2-Dipalmitoyl-3-Arachidonoyl-rac-glycerol 263386-70-5 98%
    1,2-Dipalmitoyl-3-Arachidonoyl-rac-glycerol (1,2-Palmitin-3-Arachidonin) is a triacylglycerol containing Palmitic acid and Arachidonic acid.
    1,2-Dipalmitoyl-3-Arachidonoyl-rac-glycerol
  • HY-145516
    Desmethyl Bosentan 253688-61-8 98%
    Desmethyl bosentan is an active metabolite of the endothelin receptor antagonist bosentan (HY-A0013).1 Desmethyl bosentan (25 μM) activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in a reporter assay.
    Desmethyl Bosentan
  • HY-145522
    13-Dimyristoyl-2-Eicosapentaenoyl Glycerol 191786-55-7 98%
    1,3-Dimyristoyl-2-eicosapentaenoyl glycerol (MEM) is a triacylglycerol that contains myristic acid (HY-N2041) at the sn-1 and sn-3 positions and eicosapentaenoic acid at the sn-2 position. The myristoyl groups in MEM do not affect the oxidative stability of eicosapentaenoic acid (EPA) during long-term storage at 25°C.
    13-Dimyristoyl-2-Eicosapentaenoyl Glycerol
  • HY-145527
    Hexanoyl-L-carnitine chloride 162067-53-0 99.61%
    Hexanoyl-L-carnitine (chloride) is an ester product.
    Hexanoyl-L-carnitine chloride
  • HY-145528
    Heptanoyl-L-carnitine chloride 162041-08-9 98%
    Heptanoyl-L-carnitine chloride (trans-3,4-methylene-heptanoylcarnitine) is an acylcarnitine. Heptanoyl-L-carnitine chloride causes exercise-induced alterations in the human metabolome in plasma and skeletal muscle tissue.
    Heptanoyl-L-carnitine chloride
  • HY-145535
    Tetracosanoyl-sulfatide 151122-71-3 98%
    Tetracosanoyl-sulfatide is an endogenous metabolite present in Urine that can be used for the research of Mild Metachromatic Leukodystrophy.
    Tetracosanoyl-sulfatide
  • HY-145537
    1,3-Dipalmitoyl-2-eicosapentaenoyl glycerol 148691-18-3 98%
    1,3-Dipalmitoyl-2-eicosapentaenoyl glycerol is a positional isomer of triglyceride that can affect lipid metabolism.
    1,3-Dipalmitoyl-2-eicosapentaenoyl glycerol
  • HY-145540
    1,2-Dipalmitoyl-3-Octanoyl-rac-glycerol 145134-89-0 98%
    1,2-Dipalmitoyl-3-Octanoyl-rac-glycerol is a triacylglycerol containing palmitic acid (HY-N0830) at the sn-1 and sn-2 positions and octanoic acid (HY-41417) at the sn-3 position. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Octanoic acid is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes. Octanoic acid is also a tremor-suppressing agent.
    1,2-Dipalmitoyl-3-Octanoyl-rac-glycerol
  • HY-145545
    1-Stearoyl-2-Adrenoyl-sn-glycero-3-PE 131350-53-3 98%
    1-Stearoyl-2-adrenoyl-sn-glycero-3-PE is a phospholipid that contains stearic acid (HY-B2219) and adrenic acid (HY-W013215) at the sn-1 and sn-2 positions, respectively. 1-Stearoyl-2-adrenoyl-sn-glycero-3-PE levels are inversely correlated with subject age in mitochondria isolated from human post-mortem hippocampus.
    1-Stearoyl-2-Adrenoyl-sn-glycero-3-PE
  • HY-145546
    14(15)-EpETE 131339-24-7 98%
    14(15)-EpETE is the epoxide of cytochrome P450 (CYP450) and is involved in the regulation of vascular tone and renal function.
    14(15)-EpETE
  • HY-145624
    Obeversen 2304711-30-4 98%
    Obeversen is an antisense oligonucleotide that inhibits the synthesis of diacylglycerol acyltransferase 2 (DGAT-2). Obeversen can be used in the research of nonalcoholic fatty liver disease.
    Obeversen
  • HY-145678
    α-HNJNAc 1417906-42-3 98%
    α-HNJNAc is a potent, competitive hexosaminidases inhibitor without interfering with other glycosidases.
    α-HNJNAc
  • HY-145781
    β-L-Fucopyranosyl phosphate 16562-59-7 98%
    β-L-Fucopyranosyl phosphate can be used for the research of carbohydrate metabolism. Glycosyl phosphates play crucial roles in carbohydrate metabolism as metabolic regulators or ubiquitous intermediates for glycoconjugate biosynthesis.
    β-L-Fucopyranosyl phosphate
  • HY-145952
    (2E,9Z)-Octadeca-2,9-dienoic acid 182369-03-5 98%
    (2E,9Z)-Octadeca-2,9-dienoic acid, a polyunsaturated fatty acid, can be used for the research of lipoxygenase-dependent metabolism.
    (2E,9Z)-Octadeca-2,9-dienoic acid
  • HY-14600R
    Rosiglitazone maleate (Standard) 155141-29-0 98%
    Rosiglitazone (maleate) (Standard) is the analytical standard of Rosiglitazone (maleate). This product is intended for research and analytical applications. Rosiglitazone maleate (BRL 49653C) is a potent and selective activator of PPARγ, with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, and a Kd of appr 40 nM for PPARγ; Rosiglitazone maleate is also an modulator of TRP channels, inhibits TRP melastatin 2 (TRPM2), TRPM3 and activates TRP canonical 5 (TRPC5).
    Rosiglitazone maleate (Standard)
  • HY-146084
    PCSK9 modulator-3 2476490-18-1 98%
    PCSK9 modulator-3 (Compound 13) is a potent modulator of PCSK9 with an EC50 value of 2.46 nM. PCSK9 is a recently validated target for lowering low-density lipoprotein cholesterol (LDL-C). PCSK9 modulator-3 has the potential for the research of hyperlipidemia.
    PCSK9 modulator-3
  • HY-146085
    PCSK9 modulator-4 2476490-20-5 98%
    PCSK9 modulator-4 (Compound 21) is a potent modulator of PCSK9 with an EC50 value of 0.15 nM. PCSK9 is a recently validated target for lowering low-density lipoprotein cholesterol (LDL-C). PCSK9 modulator-4 has the potential for the research of hyperlipidemia.
    PCSK9 modulator-4
  • HY-146125
    CGCG/CGG ligand 1 2488185-65-3 98%
    CGCG/CGG ligand 1 (compound 10), an anthracenone derivative, is a CGCG or CGG short spacer-ligand. CGCG/CGG ligand 1 can protect cleavable sites of DNA with the multiple CGCG or continuous CGG sites from the restriction enzyme.
    CGCG/CGG ligand 1
Cat. No. Product Name / Synonyms Application Reactivity